Human pharmacokinetics and tolerance of oral ganciclovir
نویسندگان
چکیده
منابع مشابه
Population pharmacokinetics of ganciclovir after intravenous ganciclovir and oral valganciclovir administration in solid organ transplant patients infected with cytomegalovirus.
A population pharmacokinetics analysis was performed after intravenous ganciclovir and oral valganciclovir in solid organ transplant patients with cytomegalovirus. Patients received ganciclovir at 5 mg/kg of body weight (5 days) and then 900 mg of valganciclovir (16 days), both twice daily with dose adjustment for renal function. A total of 382 serum concentrations from days 5 and 15 were analy...
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In an open-label, prospective, pharmacokinetic assessment, we evaluated total drug exposure (area under the curve [AUC]) of intravenous (IV) ganciclovir (GCV) and oral (p.o.) valganciclovir when normalized for body surface area (BSA) in pediatric liver (n=20) and renal (n=26) transplant patients Reference doses for IV GCV (200 mg/m(2)) and p.o. valganciclovir (520 mg/m(2)) were based on adult d...
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The pharmacokinetics of five dose levels of lomefloxacin (100, 200, 400, 600, and 800 mg) were examined in a single-dose, double-blind, placebo-controlled study involving 40 subjects. There were eight subjects in each group: five received active drug and three received placebo; each subject was given only one dose. All subjects completed the study, and lomefloxacin was well tolerated at all dos...
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The pharmacokinetics and safety of orally administered ciprofloxacin (Bay o 9867) were examined in 12 healthy male volunteers who received sequential doses of 250, 500, 750, and 1,000 mg. The individual and mean data were best described by biexponential disposition and elimination, assuming an apparent zero-order rate of absorption. The peak serum concentrations determined from the individual d...
متن کاملPharmacokinetics of Ganciclovir during Continuous Venovenous
ぬば ぬぱ Ganciclovir is an antiviral agent that is frequently used in critically ill patients with ぬひ cytomegalovirus (CMV) infections. Continuous venovenous haemodiafiltration (CVVHDF) is a ねど common extracorporeal renal replacement therapy in intensive care patients. Aim of this study ねな was to investigate the pharmacokinetics of ganciclovir in anuric patients undergoing CVVHDF. ねに Population ph...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1987
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.31.8.1251