Human papillomavirus 13 L1 gene polimorphism: first report

Introduction. Human papillomavirus 13 (HPV-13) belonging to Alphapapillomavirus-10 species, is an oral mucosotropic virus phylogenetically related others human (6, 11, 44, 55 and 74). It causes Multifocal Epithelial Hyperplasia, uncommon benign disease reported mainly amongst ethnic groups from America. Objective. To describe the genetic variability of HPV-13 L1 gene. Material Methods. A retrospective study including 50 samples patients with 25 asymptomatic carriers HPV-13, all subjects living in Mayan area Mexico. fragment 240 bp corresponding HPV 13L1 gene, which encodes major capsid protein was amplified, sequenced, compared only two reference sequence available. phylogenetic tree constructed using PAUP* software. Results. Eight single nucleotide polymorphisms were identified three synonymous polymorphism five non-synonymous. According tree, variants grouped branches. Conclusion: This first HPV-13. dominant shared by identified.