Human norepinephrine metabolism

Human norepinephrine metabolism. Its evaluation bydministration of tritiated norepinephrine.

It has become increasingly apparent that evaluation of human norepinephrine metabolism simply by assay of catecholamines in urine is inadequate for differentiation of many physiological or pathological states. In an attempt to examine norepinepherine metabolism in the human subject, tritium-labeled d,l-norepinephrine was administered to 11 normal adults and the definitive turnover rates and rel...

Norepinephrine Metabolism in Humans

The present study was undertaken to quantify more precisely and to begin to address the problem of heterogeneity of the kinetics of distribution and metabolism of norepinephrine (NE) in humans, by using compartmental analysis. Steadystate NE specific activity in arterialized plasma during I3HINE infusion and postinfusion plasma disappearance of [3HINE were measured in eight healthy subjects in ...

Prostaglandin and norepinephrine metabolism: effect of indomethacin on prostaglandin synthesis and norepinephrine turnover rate.

Altered norepinephrine turnover and metabolism in diabetic cardiomyopathy.

Cardiac norepinephrine turnover and metabolism were examined in rats 8 weeks after the induction of chronic diabetes by an intravenous injection of streptozotocin (65 mg/kg). Cardiac norepinephrine concentration, norepinephrine turnover, and norepinephrine uptake were markedly increased in chronic diabetes in comparison with control values; these changes were reversible by 28-day insulin therap...

Storage and metabolism of norepinephrine after experimental myocardial infarction.

MATHES, PETER, CHARLES COWAN, AND SIGMUNDUR GUDBJARNASON. Storage and metabolism of norepinephrine after experimental myocar dial infarction. Am. J. Physiol. 220(l) : 27-32. 1971.-Serial determinations of the norepinephrine (NE) content in all four chambers of the canine heart were carried out following experimental myocardial infarction. Myocardial NE retention and subcellular distribution wer...