Human nonspecific suppressive lymphokines

Lymphokines and monokines as regulators of human lymphoproliferation.

The development of a competent immunoregulatory response in the face of an antigenic challenge is modulated by soluble proteins of relatively low molecular mass. Lymphokines and monokines, secreted by cells of T lineage and cells of the monocyte/microphage series, respectively, function in a bimodal amplification network that results in the proliferation and differentiation of the immunoregulat...

Allergic Disorders: Profile of Lymphokines

Atopy is a disease characterised by a genetic disorder that manifests itself, via the increased capacity of the B Lymphocytes, in the production of IgE antibodies against some ubiquitous antigens (allergens) that can trigger an immune response after inhalation, ingestion or penetration of the skin. CD4+ Lymphocytes play a very important part in causing the production of IgE by the B Lymphocytes...

Intracellular activation of human and rodent macrophages by human lymphokines encapsulated in liposomes.

Cell-free culture supernatant fluids rich in macrophage-activating factor (MAF) activity were obtained from mitogen-stimulated human peripheral blood mononuclear leukocytes (MNL). The MAF preparations were incubated with human peripheral blood monocytes, rat alveolar macrophages (AM), and mouse peritoneal exudate macrophages (PEM). Only human monocytes were rendered tumorilytic against the huma...

Tumoricidal activity of human monocytes activated in vitro by free and liposome-encapsulated human lymphokines.

Human peripheral blood mononuclear cells from normal donors obtained by separation on a Percoll gradient were incubated with free or liposome-entrapped lymphokines produced from concanavalin A-stimulated lymphocytes and then were tested for cytotoxic activity against tumor cells. The treated monocytes lysed tumorigenic melanoma and glioblastoma target cells, but had no effect on three types of ...

Inflammatory and Human Human TNF Can Induce Nonspecific