Human NKT Cells Mediate Antitumor Cytotoxicity Directly by Recognizing Target Cell CD1d with Bound Ligand or Indirectly by Producing IL-2 to Activate NK Cells
نویسندگان
چکیده
منابع مشابه
Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells.
alpha-Galactosylceramide (alphaGalCer) stimulates NKT cells and has antitumor activity in mice. Murine NKT cells may directly kill tumor cells and induce NK cell cytotoxicity, but the mechanisms are not well defined. Newly developed human CD1d/alphaGalCer tetrameric complexes were used to obtain highly purified human alphaGalCer-reactive NKT cell lines (>99%), and the mechanisms of NKT cell cyt...
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Human Va24 NKT cells bearing an invariant Va24JaQ antigen receptor, the counterpart of the murine Va14 NKT cells, are activated by the specific ligand, a-galactosylceramide (a-GalCer) in a CD1d-dependent manner. Here, we demonstrate that the a-GalCer-activated Va24 NKT cells exert a potent perforin-dependent cytotoxic activity against a wide variety of human tumor cell lines. In addition, we de...
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In the course of inflammatory responses in peripheral tissues, NK cells may be exposed to cytokines such as IL-12 and IL-4 released by other cell types that may influence their functional activities. In the present study we comparatively analyzed purified human peripheral blood NK cells that had been exposed to either IL-12 or IL-4 during short (overnight) incubation. We show that although IL-1...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2001
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.167.6.3114