Human monoclonal anti-phospholipid antibodies selectively bind to membrane phospholipid andβ2-glycoprotein I (β2-GPI) on apoptotic cells
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چکیده
منابع مشابه
Inhibition of Apc Anticoagulant Activity on Oxidized Phospholipid by Anti-β2-glycoprotein I Monoclonal Antibodies
This research was supported by a Specialized Center on Thrombosis grant awarded by the National Heart, Lung and Blood Institute of the National Institutes of Health (grant no. P50 HL54502; NLE). CTE is an investigator of the Howard Hughes Medical Institute and holds the Lloyd Noble Chair in Cardiovascular Research at the Oklahoma Medical Research Foundation. *O. Safa current address: Biomerieux...
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Activated protein C (APC) anticoagulant activity and the ability to be inhibited by auto-antibodies associated with thrombosis are strongly augmented by the presence of phosphatidylethanolamine (PE) and phospholipid oxidation. beta(2)-glycoprotein I (beta(2)-GPI) is a major antigen for antiphospholipid antibodies present in patients with the antiphospholipid syndrome. We therefore investigated ...
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Following a meeting at Sapporo, Japan, an international consensus statement on preliminary classification criteria for definite anti-phospholipid syndrome was published.1 This set of criteria is divided into the clinical part which includes vascular thrombosis and pregnancy morbidity and the laboratory part which includes anti-cardiolipin (aCL) antibody and lupus anti-coagulant tests. Diagnosis...
متن کاملOptimization of Unnicked β2-Glycoprotein I and High Avidity Anti-β2-Glycoprotein I Antibodies Isolation
Patient biological material for isolation of β2-glycoprotein I (β2GPI) and high avidity IgG anti-β2-glycoprotein I antibodies (HAv anti-β2GPI) dictates its full utilization. The aim of our study was to evaluate/improve procedures for isolation of unnicked β2GPI and HAv aβ2GPI to gain unmodified proteins in higher yields/purity. Isolation of β2GPI from plasma was a stepwise procedure combining n...
متن کاملAnti-phospholipid Antibodies and Thrombosis
The paper gives some preliminary comments on the submissions to Discovery Challenge on Thrombosis data.
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2000
ISSN: 0009-9104
DOI: 10.1046/j.1365-2249.2000.01161.x