Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes
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چکیده
منابع مشابه
Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes
Functional consequences for most inflammatory disease-associated loci are incompletely defined, including in the LACC1 (C13orf31) region. Here we show that human peripheral and intestinal myeloid-derived cells express laccase domain-containing 1 (LACC1); LACC1 is expressed in both the cytoplasm and mitochondria. Upon NOD2 stimulation of human macrophages, LACC1 associates with the NOD2-signalli...
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With a goal of obtaining the engineering probiotics that can produce both lactic acid and laccase, Pleurotus eryngii was selected as the test material. First, the laccase gene (Lacc1) was cloned by using RT-PCR (the length of which is 1596 bp), and then, the gene was ligated to the food-grade vector pMG36e from Lactobacillus buchneri. The recombinant expression vector pMG36e-Lacc1 was construct...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/ncomms15614