Human kallikrein gene delivery protects against gentamycin-induced nephrotoxicity in rats
نویسندگان
چکیده
منابع مشابه
Nephroprotection of lacidipine against gentamycin-induced nephrotoxicity in albino rats.
AIM Gentamycin, a widely-used aminoglycoside antibiotic, is recognized as possessing significant nephrotoxic potential in human beings. Gentamycin-induced nephrotoxicity is suggested to be mediated via reactive oxygen species. The present study investigated the possible antioxidant nephroprotective effect of lacidipine as a calcium-channel blocker in a gentamycin-induced nephrotoxicity model in...
متن کاملGentamycin Induced Nephrotoxicity in Albino Mice
Twelve, male albino mice, aged 6-8 weeks, were injected intraperitoneally, aqueous solution of gentamicin (80 mg / kg / day) for fifteen days and the effects observed on the kidney structure and function. Group A served as control while Group B was given gentamicin. At the end of the experiment, blood was drawn from each animal by cardiac puncture for renal function tests and kidneys were fixed...
متن کاملKallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis.
BACKGROUND Our previous study showed that kallikrein gene transfer protects against gentamicin-induced nephrotoxicity and enhances renal function. In this study, we investigated the effects and potential mechanisms of kallikrein/kinin on inflammation and apoptosis induced by gentamicin. METHODS Rats were injected subcutaneously with gentamicin daily for 10 days and received an intravenous inj...
متن کاملLipocalin2 Protects Human Embryonic Kidney Cells against Cisplatin–Induced Genotoxicity
Cisplatin is one of the most useful chemotherapeutics which performs its cytotoxic effectvia accumulation of platinum resulting in oxidative stress, and destruction of cell DNA. Thiscould probably cause secondary cancers in healthy tissues. Lipocalin2 (Lcn2) is a protein whichits expression is increased in oxidative stresses. Therefore, the present study was performedto evaluate the protective ...
متن کاملLipocalin2 Protects Human Embryonic Kidney Cells against Cisplatin–Induced Genotoxicity
Cisplatin is one of the most useful chemotherapeutics which performs its cytotoxic effectvia accumulation of platinum resulting in oxidative stress, and destruction of cell DNA. Thiscould probably cause secondary cancers in healthy tissues. Lipocalin2 (Lcn2) is a protein whichits expression is increased in oxidative stresses. Therefore, the present study was performedto evaluate the protective ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1998
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.1998.00867.x