منابع مشابه
Human housekeeping genes are compact.
Genome Biol. 2, 1018 13 Gray, M.W. et al. (1999) Mitochondrial evolution. Science 283, 1476–1481 14 Lang, B.F. et al. (1999) A comparative genomics approach to the evolution of eukaryotes and their mitochondria. J. Eukaryot. Microbiol. 46, 320–326 15 Henze, K. and Martin, W. (2001) How do mitochondrial genes get into the nucleus? Trends Genet. 17, 383–387 16 Chinnery, P.F. (2003) Searching for ...
متن کاملOn the nature of human housekeeping genes.
Using a collection of expressed sequence tag (EST) data, we re-evaluated the correlation of tissue specificity with genomic structure, phyletic age, evolutionary rate and promoter architecture of human genes. We found that housekeeping genes are less compact and older than tissue-specific genes, and they evolve more slowly in terms of both coding and core promoter sequences. Housekeeping genes ...
متن کاملDo Housekeeping Genes Exist?
The searching of human housekeeping (HK) genes has been a long quest since the emergence of transcriptomics, and is instrumental for us to understand the structure of genome and the fundamentals of biological processes. The resolved genes are frequently used in evolution studies and as normalization standards in quantitative gene-expression analysis. Within the past 20 years, more than a dozen ...
متن کاملNon-housekeeping genes expressed in human trabecular meshwork cell cultures
PURPOSE To identify non-housekeeping genes definitively expressed in the human trabecular meshwork (TM). METHODS Microarray gene expression data on TM cultured cells from four studies were compared. Genes that were queried in at least three studies and assessed to be expressed in at least three studies were considered definitively expressed genes of the human TM. Housekeeping genes were remov...
متن کاملIdentification of Human Housekeeping Genes and Tissue-Selective Genes by Microarray Meta-Analysis
BACKGROUND Categorizing protein-encoding transcriptomes of normal tissues into housekeeping genes and tissue-selective genes is a fundamental step toward studies of genetic functions and genetic associations to tissue-specific diseases. Previous studies have been mainly based on a few data sets with limited samples in each tissue, which restrained the representativeness of their identified gene...
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ژورنال
عنوان ژورنال: Trends in Genetics
سال: 2003
ISSN: 0168-9525
DOI: 10.1016/s0168-9525(03)00140-9