Human Gene Targeting Favors Insertions Over Deletions

Over Channels with Insertions , Deletions and Substitutions 1

Systematic Analysis of microRNA Targeting Impacted by Small Insertions and Deletions in Human Genome

MicroRNAs (miRNAs) are small noncoding RNA that play an important role in posttranscriptional regulation of mRNA. Genetic variations in miRNAs or their target sites have been shown to alter miRNA function and have been associated with risk for several diseases. Previous studies have focused on the most abundant type of genetic variations, single nucleotide polymorphisms (SNPs) that affect miRNA...

Contextual Insertions/Deletions and Computability

We investigate two generalizations of insertion and deletion of words, that have recently become of interest in the context of molecular computing. Given a pair of words (x, y), called a context, the (x, y)-contextual insertion of a word v into a word u is performed as follows. For each occurrence of xy as a subword in u, we include in the result of the contextual insertion the words obtained b...

Synchronization from Insertions and Deletions

We study the problem of synchronizing two files X and Y at two distant nodes A and B that are connected through a two-way communication channel. We assume that file Y at node B is obtained from file X at node A by inserting and deleting a small fraction of symbols in X . More specifically, we consider the case where X is a non-binary non-uniform string, and deletions and insertions happen unifo...

Insertions and Deletions Target Lineage-Defining Genes in Human Cancers

Certain cell types function as factories, secreting large quantities of one or more proteins that are central to the physiology of the respective organ. Examples include surfactant proteins in lung alveoli, albumin in liver parenchyma, and lipase in the stomach lining. Whole-genome sequencing analysis of lung adenocarcinomas revealed noncoding somatic mutational hotspots near VMP1/MIR21 and ind...