Human fibroblast?derived extracellular vesicles promote hair growth in cultured human hair follicles
نویسندگان
چکیده
Hair loss is a prevalent medical condition affecting both genders. In this study, we investigate the effects of specific class extracellular vesicles (EVs), namely human normal fibroblast-derived EVs (hFB-EVs), on dermal papilla (DP) and outer root sheath (ORS) cells examine molecular mechanisms responsible for hair growth in follicles (HFs). We find that Wnt3a, which maintains hair-generating activity DP cells, enriched more strongly associated with hFB-EVs than fibroblasts. Furthermore, hFB-EV-associated Wnt3a mediated receptor activation cultured leading to an increase ?-catenin cytoplasm its translocation into nucleus, thereby elevating expression target genes Axin2 Lef1. Additionally, promoted migration, proliferation, differentiation ORS elongation shaft HFs. These findings revealed novel mechanism by influence growth.
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2021
ISSN: ['0014-5793', '1873-3468']
DOI: https://doi.org/10.1002/1873-3468.14050