Human DNA polymerase iota: wrong for the right reasons.
نویسندگان
چکیده
منابع مشابه
Human DNA polymerase iota: wrong for the right reasons.
In a recent collaborative study, Thomas A. Kunkel, director of the NIEHS Environmental Biology Program, NIEHS deputy director Samuel H. Wilson, and Roger Woodgate, an investigator at the National Institute of Child Health and Human Development, report novel findings about DNA repair and genome stability in humans. Woodgate's laboratory recently discovered and purified polymerase iota (pol ι), o...
متن کاملRight and Wrong Reasons for Compositionality
In this paper I would like to cast a critical look on the potential reasons for compositionality. I will, in particular, evaluate if and to which extent the most often cited reasons in favor of compositionality, viz. productivity, systematicity and inferentiality – each taken as properties of either language or cognition – may be justly regarded as justifications for compositionality. The resul...
متن کاملRight and wrong reasons to be screened.
How would you feel if you found out that your 85-yearold mother (or grandmother, if you prefer) had just undergone a pelvic examination to obtain a routine Pap smear? Perhaps you’d be pleased, believing she was being provided the best possible preventive care for cervical cancer. Maybe you’d be reassured, seeing it as evidence that her doctor still cares about her. Perhaps you’d be angry, viewi...
متن کاملObserving a DNA Polymerase Choose Right from Wrong
DNA polymerase (pol) β is a model polymerase involved in gap-filling DNA synthesis utilizing two metals to facilitate nucleotidyl transfer. Previous structural studies have trapped catalytic intermediates by utilizing substrate analogs (dideoxy-terminated primer or nonhydrolysable incoming nucleotide). To identify additional intermediates during catalysis, we now employ natural substrates (corr...
متن کاملHuman DNA polymerase iota protects cells against oxidative stress.
Human DNA polymerase iota (poliota) is a unique member of the Y-family of specialised polymerases that displays a 5'deoxyribose phosphate (dRP) lyase activity. Although poliota is well conserved in higher eukaryotes, its role in mammalian cells remains unclear. To investigate the biological importance of poliota in human cells, we generated fibroblasts stably downregulating poliota (MRC5-pol io...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2001
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.109-a310