Human Chorionic Gonadotropin (hCG) Up-Regulates wnt5b and wnt7b in the Mammary Gland, and hCGβ Transgenic Female Mice Present with Mammary Gland Tumors Exhibiting Characteristics of the Wnt/β-Catenin Pathway Activation
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منابع مشابه
Mammary Gland in Mice
Microvascular changes in the mammary gland in mice during pregnancy and lactation were investigated by scanning electron microscopy (SEM) with a corrosion cast method, tvansmission e]eetron microscopy (TEM) and morphometry. By SEM, duct-associated capillary plexuses were sparsety distributed to branch into adipocytes during virgin period. With advance in pregnancy, both branches from the capMar...
متن کاملGFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice.
To examine the behavior of tumor cells in tumors developing directly from mammary tissue in transgenic models, we have evaluated transgenic mice expressing green fluorescent protein (GFP). Using the mouse mammary virus promoter (MMTV) to directly drive expression of GFP, we find low levels of fluorescence in the mammary and salivary glands of transgenic animals. Using MMTV-Cre or WAP-Cre in com...
متن کاملPossible Types of Mammary Gland Tumors in Mice*
Tumors which develop in susceptible or nonsusceptible mammary tissues may have the same histological structure, but as the inherited characteristics of the mammary glands are not identical their growths may, perhaps, result from different causes. How may these differences be demonstrated? By observing the incidence of mammary tumors in the progeny of cancerous (and some noncancerous) mothers, i...
متن کاملMammary Tumors in Transgenic Mice
Heterozygous female mice carrying a targeted mutation of the Ets2 transcription factor gene were mated with a mouse strain that develops mammary tumors due to the expression of the polyoma virus middle T oncogene. Tumors from females with only one wild-type Ets2 gene were approximately one-half the size of tumors from controls. The smaller size of the tumors was correlated with a more different...
متن کاملMammary gland tumors in three male dogs
Mammary gland tumors are very rare in male dogs. In this study, four mammary gland tumors from 3 male dogs (2 intact, 1 neutered) were collected from local animal hospitals. The dogs included two purebred Shih Tzu (1 intact, 1 neutered) and one intact purebred Cocker Spaniel. The mean age of dogs with mammary gland tumors was 9 years (5-12 years). Two dogs had a solitary mass, whereas one dog h...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2007
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2007-0249