Human cellular prion protein interacts directly with clusterin protein
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چکیده
منابع مشابه
Cell-surface prion protein interacts with glycosaminoglycans.
We used ELISA and flow cytometry to study the binding of prion protein PrP to glycosaminoglycans (GAGs). We found that recombinant human PrP (rPrP) binds GAGs including chondroitin sulphate A, chondroitin sulphate B, hyaluronic acid, and heparin. rPrP binding to GAGs occurs via the N-terminus, a region known to bind divalent cations. Additionally, rPrP binding to GAGs is enhanced in the presenc...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2008
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2008.08.004