Human brain structural change related to acute single exposure to sarin
نویسندگان
چکیده
منابع مشابه
Acute exposure to sarin increases blood brain barrier permeability and induces neuropathological changes in the rat brain: dose-response relationships.
We hypothesize that a single exposure to an LD(50) dose of sarin induces widespread early neuropathological changes in the adult brain. In this study, we evaluated the early changes in the adult brain after a single exposure to different doses of sarin. Adult male rats were exposed to sarin by a single intramuscular injection at doses of 1, 0.5, 0.1 and 0.01 x LD(50). Twenty-four hours after th...
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Epinephrine-induced arrhythmias (EPIA) are known to be associated with local cardiac cholinergic activation. The present study examined the development of QT prolongation and the effect on EPIA of whole-body exposure of animals to a potent acetylcholine esterase inhibitor. Freely moving rats were exposed to sarin vapor (34.2 +/- 0.8 microg/liter) for 10 min. The electrocardiograms (ECG) of expo...
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We have studied sarin-induced global gene expression patterns at an early time point (15 min; 0.5xLD50) and a later time point (3 months; 1xLD50) using Affymetrix: Rat Neurobiology U34 chips in male, Sprague-Dawley rats and have identified a total of 65 (early) and 38 (late) genes showing statistically significant alterations from control levels at 15 min and 3 months, respectively. At the earl...
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The effects of electromagnetic fields (EMFs) radiation at the frequency of 940 MHz on the structure and function of human adult and fetal hemoglobin (HbA and HbF) were studied. After extraction and purification of HbA and HbF, the oxygen absorption values for exposed and unexposed HbA and HbF to EMF were compared. The slope of oxygen absorption curve for exposed HbA was increased while that for...
متن کاملMonitoring Structural Change in the Brain: Application to Neurodegeneration
Magnetic resonance imaging (MRI) is used in clinical routine to map the brain’s morphology. Structural changes due to brain growth, aging, surgical intervention or pathological processes may be detected by image registration of time-series imaging data. To monitor structural change a three step approach is pursued here: (1) rigid registration and intensity matching of an initial (reference) and...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2007
ISSN: 0364-5134,1531-8249
DOI: 10.1002/ana.21024