Human biomonitoring initiative (HBM4EU): Human biomonitoring guidance values (HBM-GVs) derived for bisphenol A

The “European Human Biomonitoring Initiative” (HBM4EU) derives human biomonitoring guidance values (HBM-GVs) for the general population (HBM-GVGenPop) and/or occupationally exposed adults (HBM-GVWorker) several priority substances and substance groups as identified by policy makers, scientists stakeholders at EU national level, including bisphenol A (BPA). exposure to BPA is widespread of particular concern because its known endocrine-disrupting properties. Unlike conjugated forms circulating in body, free interact with nuclear estrogen receptors. Because considered be more toxicologically active than (e.g. BPA-glucuronide (BPA-G) BPA-sulfate (BPA-S)), measurement blood provides superior surrogate biologically effective dose. However, considering difficulty implementing sampling large HBM cohorts, well current analytical capacities complying quality assurance (QA)/quality control (QC) schemes, total urine (i.e. sum measured after an hydrolysis phase II metabolites) was retained relevant biomarker BPA. HBM-GVGenPop 230 µg/L 135 children, respectively, were developed on basis toxicological data. To derive these values, concentrations urinary consistent a steady-state temporary Tolerable Daily Intake (t-TDI) 4 µg/kg bw/day set 2015 European Food Safety Authority (EFSA) estimated. physiologically-based pharmacokinetic (PBPK) model Karrer et al. (2018) used, assuming oral t-TDI level averaged over 24 h. Dermal uptake suspected contribute substantially body burden, which comparison route, generating higher ratio blood. Therefore, alternative approach calculating according estimated relative contributions both dermal routes global also discussed. Regarding workplace, concentration that would generate same plasma (considered bioactive form) h-averaged intake Chemicals Agency (ECHA)’s DNEL 8 µg BPA/kg workers. predicted equivalent to, or exceeds 95th percentile different studies conducted population. Thus, no HBM-GVWorker proposed, high background coming from environmental - mostly through food making discrimination occupational difficult.