Human adiponectin receptor AdipoR1 assumes closed and open structures
نویسندگان
چکیده
منابع مشابه
in vitro Anti-Proliferative Effect of Adiponectin on Human Endometriotic Stromal Cells through AdipoR1 and AdipoR2 Gene Receptor Expression
Background: Endometriosis is a complex disorder in reproductive age women which consist of stromal and epithelial cells implantation outside the uterine cavity. Adiponectin is a member of cytokine family with various metabolic roles and proliferation inhibition of many cancer cells. The aim of the present research was to determine adiponectin effect on human endometriotic stromal cells (ESCs) p...
متن کاملStructures of closed and open conformations of dimeric human ATM
ATM (ataxia-telangiectasia mutated) is a phosphatidylinositol 3-kinase-related protein kinase (PIKK) best known for its role in DNA damage response. ATM also functions in oxidative stress response, insulin signaling, and neurogenesis. Our electron cryomicroscopy (cryo-EM) suggests that human ATM is in a dynamic equilibrium between closed and open dimers. In the closed state, the PIKK regulatory...
متن کاملin vitro anti-proliferative effect of adiponectin on human endometriotic stromal cells through adipor1 and adipor2 gene receptor expression
background: endometriosis is a complex disorder in reproductive age women which consist of stromal and epithelial cells implantation outside the uterine cavity. adiponectin is a member of cytokine family with various metabolic roles and proliferation inhibition of many cancer cells. the aim of the present research was to determine adiponectin effect on human endometriotic stromal cells (escs) p...
متن کاملAnti-Proliferative Effect of Adiponectin on Human Endometriotic Stromal Cells through AdipoR1 and AdipoR2 Gene Receptor Expression
Background: Endometriosis is a complex disorder in reproductive age women which consist of stromal and epithelial cells implantation outside the uterine cavity. Adiponectin is a member of cytokine family with various metabolic roles and proliferation inhibition of many cancer cells. The aim of the present research was to determine adiponectin effect on human endometriotic stromal cells (ESCs) p...
متن کاملAdiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance.
Considerable data support adiponectin as an important adipose-derived insulin sensitizer that enhances fatty acid oxidation and alters hepatic gluconeogenesis. Adiponectin acts by way of two receptors, ADIPOR1 and ADIPOR2. ADIPOR1 is widely expressed in tissues, including muscle, liver, and pancreas, and binds the globular form of adiponectin with high affinity. To test the hypothesis that sequ...
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ژورنال
عنوان ژورنال: Communications Biology
سال: 2020
ISSN: 2399-3642
DOI: 10.1038/s42003-020-01160-4