Hsa_circ_0079598 acts as a potential diagnostic and prognostic biomarker for gastric cancer

Abstract Objectives The work discussed the expression level circular RNA (circRNA) hsa_circ_0079598 for gastric cancer (GC) patients as well clinicopathological significance. Methods qRT-PCR was utilized determining of in GC cell lines, 40 tissue pairs and their paracancerous specimens, 60 preoperative postoperative plasma specimens patients, 20 with polyps, healthy control group. Besides, correlation parameters analyzed. Tumor indices glycan antigen 199 (CA199), 724 (CA724), pepsinogen I (PGI) were combined to evaluate auxiliary diagnostic value. values prognosis analyzed using survival curves. Results relative cancerous tissues lower than that (p=0.004). group (p<0.001) polyps. Moreover, human epithelial lines (GES-1) (p<0.05) higher HGC-27, AGS, MGC-803 lines. total time high-expression patient (p=0.040) low-expression related differentiated degree tumors TNM staging (p<0.05). value ROC When distinguished from polyps group, areas under curve (AUCs) 0.856 0.930, respectively. Hsa_circ_0079598 tumor CA199, CA724, PGI detection had specificity accuracy those a single index. Conclusions plasma, tissues, which progress GC. can improve diagnosis