HPV RNA CISH score identifies two prognostic groups in a p16 positive oropharyngeal squamous cell carcinoma population
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چکیده
منابع مشابه
Induction Chemotherapy for p16 Positive Oropharyngeal Squamous Cell Carcinoma
OBJECTIVES/HYPOTHESIS We aimed to determine the effectiveness of induction chemotherapy for treating p16-positive oropharyngeal cancer in our department. STUDY DESIGN This was a retrospective case series to assess treatment effectiveness. METHODS We administered induction chemotherapy to patients with stage III to IV oropharyngeal p16-positive squamous cell carcinoma between 2008 and 2013. ...
متن کاملAsymptomatic p16-positive oropharyngeal squamous cell carcinoma: an emerging trend.
IMPORTANCE The rapid increase of human papillomavirus-associated oropharyngeal cancer has demonstrated a need for new strategies in prevention, diagnosis, evaluation, and treatment. Because there are currently no available screening technologies to detect early disease, a trend of purely incidentally identified asymptomatic p16-positive squamous cell carcinoma has been observed. We identify and...
متن کاملPre-radiotherapy feeding tube identifies a poor prognostic subset of postoperative p16 positive oropharyngeal carcinoma patients
BACKGROUND This study explores variables associated with poor prognosis in postoperative p16 positive oropharyngeal squamous cell carcinoma (OPSCC) patients undergoing adjuvant radiotherapy or chemoradiotherapy. Specifically, analysis was done related to timing of feeding tube insertion relative to radiotherapy. METHODS From 1997-2009, of 376 consecutive patients with OPSCC, 220 received adju...
متن کاملBone Marrow Failure in HPV-Associated Oropharyngeal Squamous Cell Carcinoma
Oropharyngeal tumours account for more than 500,000 cases annually worldwide [1,2]. The incidence rate in males exceeds 20 per 100,000 in regions of Hong Kong, the Indian subcontinent, parts of Europe and among African Americans in the United States [3]. In Europe, there were approximately 250,000 cases and 63,500 deaths in 2012 [4]. A 2013 study designed to determine the prevalence of HPV-posi...
متن کاملMatted nodes: poor prognostic marker in oropharyngeal squamous cell carcinoma independent of HPV and EGFR status.
BACKGROUND Despite better prognosis, there is a group of oropharyngeal squamous cell carcinoma (SCC) human papillomavirus (HPV)+ patients who experience treatment failure and succumb to distant metastasis. METHODS Seventy-eight previously untreated patients nested in a concurrent chemoradiation protocol were reviewed to correlate patterns of local-regional tumor extent to distant metastasis. ...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2018
ISSN: 0893-3952,1530-0285
DOI: 10.1038/s41379-018-0090-y