HPV IMMUNOHISTOCHEMICAL TESTING AND CERVICAL DYSPLASIA

HPV immunohistochemical testing and cervical dysplasia

BACKGROUND AND AIM HPV (Human Papilloma Virus) infection represents a necessary condition for cervical carcinogenesis. The purpose of this study was to evaluate the efficiency of HPV testing using an immunohistochemical staining kit with implications upon both diagnosis and treatment of cervical intraepithelial neoplasia (CIN). METHODS Seventy-nine patients and eighty-six controls were enroll...

The degree of agreement between HPV testing, pap smear and colposcopy in cervical dysplasia diagnosis.

MATERIAL AND METHODS The current study analyzed the degree of agreement between HPV testing, Pap smear, and colposcopic directed cervical biopsies. The study was performed on a group of 332 patients diagnosed and treated for cervical dysplasia at Cuza-Vodă Obstetrics-Gynecology Clinic Hospital and Suceava County Hospital between 2006 and 2011. RESULTS 190 patients (57.23%) were positive for H...

MicroRNA expressions in HPV-induced cervical dysplasia and cancer.

BACKGROUND/AIM The role of oncogenic or high-risk human papillomavirus (HPV) in cervical carcinogenesis is inevitable, yet not fully understood. Detailed analysis of microRNA (miRNA) alterations occurring during high-risk HPV transformation will increase our current understanding over cervical carcinogenesis. The two main aims of the study were: (i) finding association between HPV infection cha...

MicroRNA Expressions in HPV-induced Human Cervical Dysplasia and Cancer

TNFalpha polymorphism frequencies in HPV-associated cervical dysplasia.

OBJECTIVES Persistent high-risk HPV infection of the uterine cervix is associated with CIN and cervical carcinoma. Women with a reduced pro-inflammatory response to HPV are likely to be susceptible to viral persistence, and therefore, potentially more vulnerable to cervical neoplasia. In this study, we investigate whether nucleotide sequence polymorphisms in the TNFalpha (TNFSF2) gene (which ca...