HPLC/DAD determination of rosmarinic acid in Salvia officinalis: sample preparation optimization by factorial design
نویسندگان
چکیده
منابع مشابه
Establishment of Salvia officinalis L. hairy root cultures for the production of rosmarinic acid.
Shoots of Salvia officinalis, a medicinally important plant, were infected with Agrobacterium rhizogenes strains ATCC 15834 and A4 which led to the induction of hairy roots in 57% and 37% of the explants, respectively. Seven lines of hairy roots were established in WP liquid medium under light and dark conditions. The transformed nature of the root lines was confirmed by polymerase chain reacti...
متن کاملPermeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco-2 cell monolayers.
ETHNOPHARMACOLOGICAL RELEVANCE Rosmarinic acid (RA), a caffeic acid-related compound found in high concentrations in Prunella vulgaris (self-heal), and ursolic acid (UA), a pentacyclic triterpene acid concentrated in Salvia officinalis (sage), have been traditionally used to treat inflammation in the mouth, and may also be beneficial for gastrointestinal health in general. AIM OF THE STUDY To...
متن کاملExtraction and determination of flavonoids in the leaf, extract, and in a pharmaceutical tablet preparation of Salvia officinalis by HPLC
This research was undertaken to attain a standard extract from the leaves of Salvia officinalis for use in a tablet dosage form, and to identify and determine the active components in the leaf, extract, and in Sweatosan as the standard tablet dosage form. It has previously been reported that an aqueous infusion and a dried aqueous extract, in an open study with 80 patients comparably reduced sw...
متن کاملExtraction and determination of flavonoids in the leaf, extract, and in a pharmaceutical tablet preparation of Salvia officinalis by HPLC
This research was undertaken to attain a standard extract from the leaves of Salvia officinalis for use in a tablet dosage form, and to identify and determine the active components in the leaf, extract, and in Sweatosan as the standard tablet dosage form. It has previously been reported that an aqueous infusion and a dried aqueous extract, in an open study with 80 patients comparably reduced sw...
متن کاملRosmarinic Acid and Melissa officinalis Extracts Differently Affect Glioblastoma Cells
Lemon balm (Melissa officinalis L.) has many biological effects but especially important is its neuroprotective activity. The aim of the study is to produce different extracts of Melissa officinalis and analyse their chemical composition and biological properties on rat glioblastoma C6 cells. Results revealed that rosmarinic acid (RA) is the predominant compound of lemon balm extracts. RA has c...
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2013
ISSN: 0103-5053
DOI: 10.1590/s0103-50532013000100012