How does xenon produce anaesthesia?

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Xenon: no stranger to anaesthesia.

Xenon derives its name from the Greek for `stranger' because of its rarity, representing no more than 8.75 3 10% of the atmosphere or 0.0875 ppm. Discovered in 1898, it is manufactured by fractional distillation of air and is used commercially for lasers, high intensity lamps, ̄ash bulbs, jet propellant in the aerospace industry, X-ray tubes, and in medicine. The total amount of xenon in the atm...

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The breast feeding mother and xenon anaesthesia: four case reports. Breast feeding and xenon anaesthesia

BACKGROUND Four nursing mothers consented to anaesthesia for urgent surgery only on condition that their ability to breast feed would not be impaired. METHODS Following induction of general anaesthesia with propofol and remifentanil, 65-69% xenon supplemented with remifentanil was used as an inhalational anaesthetic for maintenance. RESULTS After finishing surgery the women could be extubat...

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Evidence that Xenon does not produce open channel blockade of the NMDA receptor.

Previous studies had not excluded the possibility that the mechanism by which Xenon (Xe) blocks N-methyl-D-aspartate (NMDA) receptors might be that of an open-channel blocker. We tested this possibility on mutant NMDA receptors carrying an alanine (A) to cysteine (C) mutation located within the SYTANLAAF-motif of the third transmembrane region (TM3). This mutation was shown to yield constitutiv...

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Effects of xenon anaesthesia on the circulatory response to hypoventilation.

BACKGROUND Circulatory response to hypoventilation is aimed at eliminating carbon dioxide and maintaining oxygen delivery (DO(2)) by increasing cardiac output (CO). The hypothesis that this increase is more pronounced with xenon than with isoflurane anaesthesia was tested in pigs. METHODS Twenty pigs received anaesthesia with xenon 0.55 MAC/remifentanil 0.5 microg kg(-1) min(-1) (group X, n=1...

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Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia.

BACKGROUND Xenon has been proved to be safe and efficacious for general anaesthesia in numerous trials. In addition, experimental studies demonstrate that xenon inhibits the 5-hydroxytryptamine type 3 (5-HT(3)) receptor. As 5-HT(3) receptor antagonists are known to decrease postoperative nausea and vomiting (PONV) to an extent comparable with a propofol-based total i.v. technique, we tested the...

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ژورنال

عنوان ژورنال: Nature

سال: 1998

ISSN: 0028-0836,1476-4687

DOI: 10.1038/24525