How do selectins mediate leukocyte rolling in venules?
نویسندگان
چکیده
منابع مشابه
Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow.
Reversible interactions of glycoconjugates on leukocytes with P- and E-selectin on endothelial cells mediate tethering and rolling of leukocytes in inflamed vascular beds, the first step in their recruitment to sites of injury. Although selectin ligands on hematopoietic precursors have been identified, here we review evidence that PSGL-1, CD44, and ESL-1 on mature leukocytes are physiologic gly...
متن کاملAre Responsible for Preferential Leukocyte Rolling in Rat Mesenteric Venules
At the onset of the inflammatory process, leukocytes roll along venular but not arteriolar walls before they firmly attach and emigrate. To test whether differences in hydrodynamic flow conditions are responsible for the preferential occurrence of leukocyte rolling in venules, we varied wall shear rate, 'Yw, between 30 and 2,000 sec` by selective micro-occlusion of side branches in venules and ...
متن کاملL-Selectin Can Mediate Leukocyte Rolling in Untreated Mesenteric Venules In Vivo Independent of E- or P-Selectin
Granulocyte recruitment during the acute inflammatory response is initiated by their rolling along the endothelial lining of postcapillary venules. To determine whether expression of L-selectin alone is sufficient for rolling, the murine pre-B lymphocytic cell line 300.1 9, which does not bind Eor P-selectin, was transfected with human L-selectin cDNA, which led to stable L-selectin expression ...
متن کاملL-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin.
Granulocyte recruitment during the acute inflammatory response is initiated by their rolling along the endothelial lining of postcapillary venules. To determine whether expression of L-selectin alone is sufficient for rolling, the murine pre-B lymphocytic cell line 300.19, which does not bind E- or P-selectin, was transfected with human L-selectin cDNA, which led to stable L-selectin expression...
متن کاملL-Selectin Can Mediate Leukocyte Rolling in Untreated Mesenteric Venules In Vivo Independent of E- or P-Selectin
Granulocyte recruitment during the acute inflammatory response is initiated by their rolling along the endothelial lining of postcapillary venules. To determine whether expression of L-selectin alone is sufficient for rolling, the murine pre-B lymphocytic cell line 300.1 9, which does not bind Eor P-selectin, was transfected with human L-selectin cDNA, which led to stable L-selectin expression ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1992
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(92)81660-0