منابع مشابه
How and why does β-actin mRNA target?
β-Actin mRNA is localized near the leading edge in several cell types where actin polymerization is actively promoting forward protrusion. The localization of the β-actin mRNA near the leading edge is facilitated by a short sequence in the 3′UTR (untranslated region), the ‘zipcode’. Localization of the mRNA at this region is important physiologically. Treatment of chicken embryo fibroblasts wit...
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Introduction: Nursing education should develop autonomy, critical thinking, open-mindedness and sensitivity to others. Reflection seems to be an effective strategy for developing such capabilities in nursing. Therefore, this narrative review study was carried out to explore reflection in nursing education. Methods: Using keywords like reflecting, reflection and nursing reflection, FarsiandEngl...
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Background Gaming is a potentially dysfunctional consequence of performance measurement and management systems in the health sector and more generally. In 2009, the New Zealand government initiated a Shorter Stays in Emergency Department (SSED) target in which 95% of patients would be admitted, discharged or transferred from an emergency department (ED) within 6 hours. The implementation ...
متن کاملDynamics of native β-actin mRNA transport in the cytoplasm.
Transport of messenger RNAs (mRNAs) in the cytoplasm is essential for localization to translation sites and for post-transcriptional regulation. Utilizing single-RNA sensitive probes and real-time fluorescence microscopy, we accurately quantified the dynamics of native, non-engineered, β-actin mRNAs within the cytoplasm of epithelial cells and fibroblasts for the first time. Using single-partic...
متن کاملMechanism of β-actin mRNA Recognition by ZBP1
Zipcode binding protein 1 (ZBP1) is an oncofetal RNA-binding protein that mediates the transport and local translation of β-actin mRNA by the KH3-KH4 di-domain, which is essential for neuronal development. The high-resolution structures of KH3-KH4 with their respective target sequences show that KH4 recognizes a non-canonical GGA sequence via an enlarged and dynamic hydrophobic groove, whereas ...
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ژورنال
عنوان ژورنال: Biology of the Cell
سال: 2005
ISSN: 0248-4900
DOI: 10.1042/bc20040063