Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation
نویسندگان
چکیده
منابع مشابه
Hot Melt Extrusion Technique
Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-melt extrusion has been demonstrated to provide sustained, modified, and targeted drug ...
متن کاملHot-Melt Extrusion Technique: A Review
Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...
متن کاملHot-Melt Extrusion Technique: A Review
Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...
متن کاملA quality by design approach to understand formulation and process variability in pharmaceutical melt extrusion processes.
OBJECTIVES In this study, the principles of quality by design (QbD) have been uniquely applied to a pharmaceutical melt extrusion process for an immediate release formulation with a low melting model drug, ibuprofen. METHODS Two qualitative risk assessment tools - Fishbone diagram and failure mode effect analysis - were utilized to strategically narrow down the most influential parameters. Se...
متن کاملApplying Extrusion to Pharmaceutical Formulation Design
The drivers to produce solid solution formulations are reviewed together with specific challenges of implementing extrusion in a pharmaceutical setting. A solvent-based approach to screen formulations with less than 10 mg drug/screen is introduced and validated with experimental data. Process development challenges associated with the use of hygroscopic fine polymer powders are addressed throug...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2015
ISSN: 1530-9932
DOI: 10.1208/s12249-015-0360-7