منابع مشابه
Host genes and infectious diseases.
This panel presented data on host genes that influence susceptibility to or manifestations of four infectious diseases: Puumala hantavirus infection, tuberculosis (TB), Lyme disease, and AIDS. Gus Birkhead, Council of State and Territorial Epidemiologists, introduced the session, highlighting its timeliness in relation to the rapidly emerging body of data on our 100,000 human genes that stems f...
متن کاملHost Genomics in Infectious Diseases
Understanding mechanisms by which genetic variants predispose to complications of infectious diseases can lead to important benefits including the development of biomarkers to prioritize vaccination or prophylactic therapy. Family studies, candidate genes in animal models, and the absence of well-defined risks where the complications are rare all can point to genetic predisposition. The most co...
متن کاملHepcidin and Host Defense against Infectious Diseases
Hepcidin is the master regulator of iron homeostasis in vertebrates. The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli. While the role of hepcidin in iron regulation is well established, its contribution to host defense is emerging as complex and multifaceted. In this review, we summarize the literature on the role of hepcidin as a mediator of antimicrobia...
متن کاملCoupling Within-Host and Between-Host Infectious Diseases Models
Biological processes occur at distinct but interlinked scales of organization. Yet, mathematical models are often focused on a single scale. Recently, there has been a significant interest in creating and using models that link the withinhost dynamics and population level dynamics of infectious diseases. These types of multi-scale models, called immuno-epidemiological models, fall in four categ...
متن کاملGenes and Diseases
The science of medical genetics is progressing rapidly. The practical importance of this progress should be considered by medical doctors. Both genetic and environmental factors are involved in the abnormail phenotypes considered diseases. The relative significance of the two factors varies from disease to disease. All diseases can be viewed as falling on a spectrum in this regard. Hereditary...
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ژورنال
عنوان ژورنال: American Journal of Preventive Medicine
سال: 1999
ISSN: 0749-3797
DOI: 10.1016/s0749-3797(98)00143-3