Hormone Replacement Therapy and Incidence of Alzheimer Disease in Older Women<SUBTITLE>The Cache County Study</SUBTITLE>
نویسندگان
چکیده
منابع مشابه
Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study.
CONTEXT Previous studies have shown a sex-specific increased risk of Alzheimer disease (AD) in women older than 80 years. Basic neuroscience findings suggest that hormone replacement therapy (HRT) could reduce a woman's risk of AD. Epidemiologic findings on AD and HRT are mixed. OBJECTIVE To examine the relationship between use of HRT and risk of AD among elderly women. DESIGN, SETTING, AND...
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Alzheimer disease (AD) is the most common form of dementia among the elderly. A higher prevalence of AD in women than in men suggests a link between gonadal hormone levels and AD. Increasing evidence supports a role for estrogen in brain regions involved in learning and memory and in the protection and regulation of cholinergic neurons, which degenerate in AD. Despite the lack of consensus, man...
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Oestrogen alone probably confers a degree of protection against ischaemic heart disease and stroke and is appropriate for women requiring hormone replacement therapy (HRT) who have undergone hysterectomy. However, the cardiovascular effects of the progestogens used with oestrogen in the much larger number of women who have not undergone hysterectomy are unknown. Some widely used progestogens ha...
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ژورنال
عنوان ژورنال: JAMA
سال: 2002
ISSN: 0098-7484
DOI: 10.1001/jama.288.17.2123