Hormone delivery: small synthetic molecular mimics

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Hormone delivery: small synthetic molecular mimics.

Since the experimental intravenous injections of pancreatic extracts into animal models of diabetes in 1912 by Scott (1), and after the purification of insulin by Banting, Best and Collip in 1921, it remained unclear why oral administration of these extracts or insulin had no effect, until finally in 1925 Macleod showed that insulin was a peptide destroyed by proteolytic enzymes in the digestiv...

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ژورنال

عنوان ژورنال: European Journal of Endocrinology

سال: 1998

ISSN: 0804-4643,1479-683X

DOI: 10.1530/eje.0.1390481