Honokiol induces superoxide production by targeting mitochondrial respiratory chain complex I in Candida albicans
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منابع مشابه
Honokiol induces superoxide production by targeting mitochondrial respiratory chain complex I in Candida albicans
BACKGROUND Honokiol, a compound extracted from Magnolia officinalis, has antifungal activities by inducing mitochondrial dysfunction and triggering apoptosis in Candida albicans. However, the mechanism of honokiol-induced oxidative stress is poorly understood. The present investigation was designed to determine the specific mitochondrial reactive oxygen species (ROS)-generation component. MET...
متن کاملSuperoxide production by the mitochondrial respiratory chain.
Most of the oxygen consumed by aerobic organisms is reduced to water by the enzyme cytochrome c oxidase in the terminal reaction of the mitochondrial respiratory chain. Since oxygen in the ground state is in a triplet configuration (with two unpaired electrons in the outer shell) its reduction to water must occur in four consecutive one-electron steps. Some of the partially reduced oxygen inter...
متن کاملHonokiol induces reactive oxygen species-mediated apoptosis in Candida albicans through mitochondrial dysfunction
OBJECTIVE To investigate the effects of honokiol on induction of reactive oxygen species (ROS), antioxidant defense systems, mitochondrial dysfunction, and apoptosis in Candida albicans. METHODS To measure ROS accumulation, 2',7'-dichlorofluorescein diacetate fluorescence was used. Lipid peroxidation was assessed using both fluorescence staining and a thiobarbituric acid reactive substances (...
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The first and major entry point of electrons into the mitochondrial respiratory chain (MRC) 1 occurs through NADH-coenzyme Q reduc-tase (complex I). Decreased complex I activity is associated with a wide range of conditions, including inherited mitochondrial diseases and neu-rodegenerative conditions such as Parkinson disease (1–2). More than 60 natural and commercial compounds are reported to ...
متن کاملThe Assembly Pathway of Mitochondrial Respiratory Chain Complex I.
Mitochondrial complex I is the largest integral membrane enzyme of the respiratory chain and consists of 44 different subunits encoded in the mitochondrial and nuclear genome. Its biosynthesis is a highly complicated and multifaceted process involving at least 14 additional assembly factors. How these subunits assemble into a functional complex I and where the assembly factors come into play is...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2017
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0184003