Honing a harder-hitting hammerhead improves broadly neutralizing antibody breadth and potency
نویسندگان
چکیده
منابع مشابه
Dose–response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies
A new generation of HIV broadly neutralizing antibodies (bnAbs) with remarkable potency, breadth and epitope diversity has rejuvenated interest in immunotherapeutic strategies. Potencies defined by in vitro IC50 and IC80 values (50 and 80% inhibitory concentrations) figure prominently into the selection of clinical candidates; however, much higher therapeutic levels will be required to reduce m...
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PURPOSE OF REVIEW This review highlights recent developments in HIV-1 antibody engineering and discusses the effects of increased polyreactivity on serum half-lives of engineered antibodies. RECENT FINDINGS Recent studies have uncovered a wealth of information about the relationship between the sequences and efficacies of anti-HIV-1 antibodies through a combination of bioinformatics, structur...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2015
ISSN: 0021-9738
DOI: 10.1172/jci82057