Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome
نویسندگان
چکیده
منابع مشابه
Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome
NOD-like receptor (NLR) proteins (Nlrps) are cytosolic sensors responsible for detection of pathogen and danger-associated molecular patterns through unknown mechanisms. Their activation in response to a wide range of intracellular danger signals leads to formation of the inflammasome, caspase-1 activation, rapid programmed cell death (pyroptosis) and maturation of IL-1β and IL-18. Anthrax leth...
متن کاملSolution Structure of the RAIDD CARD and Model for CARD/CARD Interaction in Caspase-2 and Caspase-9 Recruitment
Apoptosis requires recruitment of caspases by receptor-associated adaptors through homophilic interactions between the CARDs (caspase recruitment domains) of adaptor proteins and prodomains of caspases. We have solved the CARD structure of the RAIDD adaptor protein that recruits ICH-1/caspase-2. It consists of six tightly packed helices arranged in a topology homologous to the Fas death domain....
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The ASC (apoptosis speck-like protein) is a key component of multimeric protein complexes that mediate inflammation and host defence. Comprising a PYD (Pyrin) domain and a CARD (caspase activation and recruitment domain), ASC functions downstream of NLRs (nucleotide-binding domain, leucine-rich repeat-containing receptors) and AIM2 (absent in melanoma 2) through the formation of supramolecular ...
متن کاملNLRP1 is an inflammasome sensor for Toxoplasma gondii.
The obligate intracellular parasite Toxoplasma gondii is able to infect nearly all nucleated cell types of warm-blooded animals. This is achieved through the injection of hundreds of parasite effectors into the host cell cytosol, allowing the parasite to establish a vacuolar niche for growth, replication, and persistence. Here we show that Toxoplasma infection actives an inflammasome response i...
متن کاملMinimum data set for electronic health card of schizophrenia
Purpose: Having a clinical information system is a good solution for monitoring medical problems. This system is designed to improve the speed and accuracy of data management. The goal is to replace medical records with a clinical information system to support storing, processing and distributing data in all the sections of a healthcare center. The purpose of this research was to determine ...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2021
ISSN: 2041-4889
DOI: 10.1038/s41419-020-03342-8