Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
نویسندگان
چکیده
منابع مشابه
Homologous recombination-deficient tumors are hyper-dependent on POLQ-mediated repair
Large-scale genomic studies have shown that half of epithelial ovarian cancers (EOCs) have alterations in genes regulating homologous recombination (HR) repair1. Loss of HR accounts for the genomic instability of EOCs and for their cellular hyper-dependence on alternative poly-ADP ribose polymerase (PARP)-mediated DNA repair mechanisms2-5. Previous studies have implicated the DNA polymerase POL...
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ژورنال
عنوان ژورنال: Nature
سال: 2015
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature14184