Homeostatic regulation of intrinsic excitability in hippocampal neurons: response to chronic depolarisation
نویسندگان
چکیده
منابع مشابه
Homeostatic regulation of intrinsic excitability 1 Homeostasis of intrinsic excitability in hippocampal neurones: dynamics and mechanism of the response to chronic depolarization
Section: Neuroscience – development/plasticity/repair Running title: Homeostatic regulation of intrinsic excitability Word count: 6960 (excluding References and Figure Legends)
متن کاملHomeostatic Plasticity of Striatal Neurons Intrinsic Excitability following Dopamine Depletion
The striatum is the major input structure of basal ganglia and is involved in adaptive control of behaviour through the selection of relevant informations. Dopaminergic neurons that innervate striatum die in Parkinson disease, leading to inefficient adaptive behaviour. Neuronal activity of striatal medium spiny neurons (MSN) is modulated by dopamine receptors. Although dopamine signalling had r...
متن کاملHomeostasis of intrinsic excitability in hippocampal neurones: dynamics and mechanism of the response to chronic depolarization.
In order to maintain stable functionality in the face of continually changing input, neurones in the CNS must dynamically modulate their electrical characteristics. It has been hypothesized that in order to retain stable network function, neurones possess homeostatic mechanisms which integrate activity levels and alter network and cellular properties in such a way as to counter long-term pertur...
متن کاملAntibiotic Supplements Affect Electrophysiological Properties and Excitability of Rat Hippocampal Pyramidal Neurons in Primary Culture
Introduction: Antibiotic supplements are regularly used in neuronal culture media to control contamination however, they can interfere with the neuronal excitability and affect electrophysiological properties. Therefore, in this study, the effect of penicillin/streptomycin supplements on the spontaneous electrophysiological activity of hippocampal pyramidal neurons was examined. Methods: Electr...
متن کاملChronic high-inspired CO2 decreases excitability of mouse hippocampal neurons.
To examine the effect of chronically elevated CO(2) on excitability and function of neurons, we exposed mice to 8 and 12% CO(2) for 4 wk (starting at 2 days of age), and examined the properties of freshly dissociated hippocampal neurons obtained from slices. Chronic CO(2)-treated neurons (CC) had a similar input resistance (R(m)) and resting membrane potential (V(m)) as control (CON). Although ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Computational Neuroscience
سال: 2008
ISSN: 1662-5188
DOI: 10.3389/conf.neuro.10.2008.01.099