Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation

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Developmental exposure to bisphenol A alters expression and DNA methylation of Fkbp5, an important regulator of the stress response

Bisphenol A (BPA), an abundant endocrine disruptor, affects stress-responsiveness and related behaviors in children. In rats, perinatal BPA exposure modifies stress response in pubertal offspring via unknown mechanisms. Here we examined possible epigenetic modifications in the glucocorticoid receptor gene and its regulator Fkbp5 in hypothalamus and hippocampus of exposed offspring. We found inc...

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ژورنال

عنوان ژورنال: Biological Psychiatry

سال: 2016

ISSN: 0006-3223

DOI: 10.1016/j.biopsych.2015.08.005