Holo-omic applications to unveil microbiome shaping sustainable horticultural production

Plant-associated microorganisms play a key role in the future sustainability of terrestrial ecosystems. In nature, plants and their associated microbiome can form an assemblage species, considered interacting metaorganisms or holobionts. Horticultural plants, including vegetables, fruit berries, ornamentals live intimate association with complex diverse microbial communities that have evolved myriad cooperative competitive interaction mechanisms shape holobiont fitness. Nonetheless, our understanding these interactions shaping more horticulture communities, along relevance for host growth, fitness, stress resilience, health natural context remains sparse. this perspective, holo-omic landscape requires careful consideration study design integrates multi-omic data from both microbiota domains is promising approach to unveil interplay between two advance horticultural production. The analysis (meta)-omics phenotyping, mechanistic experiments model systems, revolutionizing research by enhancing ability understand structure core function plant-associated microbiome. These advancements are complemented improvements throughput accuracy DNA sequencing, enabling us delve deeper into genomes communities. Yet, many challenges remain. We focus review on potential holo-omics generate holistic perspective molecular networks, we further discuss implementation current limitations within horticulture. argue will pave way improve, food security safety, sustainability, breeding practices, development microbiota- host-tailored crops’ treatments increasing production efficiency.