HLA-Matching Platelet Transfusion, Particularly in Relation to ABO-Mismatching
نویسندگان
چکیده
منابع مشابه
An evaluation of crossmatching, HLA, and ABO matching for platelet transfusions to refractory patients.
Refractoriness occurs in many patients receiving multiple platelet transfusions. We used a sensitive ELISA assay to assess the utility of crossmatching HLA-A,B matched single donor platelets in 51 consecutive, typical refractory patients. Of the 222 transfusions evaluated at 1 to 4 hours posttransfusion, only 17 of 54 (31%) with positive crossmatches had corrected platelet count increments of g...
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3 Roff SR. Underascertainment of multiple myeloma challenges robustness of third NRPB study of nuclear veterans. Published online March 7, 2003. http://bmj.com/cgi/eletters/326/7387/468/d# 30234 (accessed June 30, 2003). 4 Johnson JC, Thaul S, Page WF, Crawford H. Mortality of Veteran Participants in the CROSSROADS Nuclear Test. Washington, DC: National Academy Press, 1996. 5 Darby SC, Kendall ...
متن کاملPlatelet transfusion therapy for alloimmunized patients: selective mismatching for HLA B12, an antigen with variable expression on platelets.
There can be wide variation in the expression of the HLA B12 antigen and its "splits," B44 and 45, on the platelets and lymphocytes from the same individual. One hundred sixty-two single donor platelet transfusions mismatched only for this antigen group were administered to 54 alloimmunized patients who were refractory to random donor platelets. Satisfactory increments (one-hour post-transfusio...
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In this issue, Kosmoliaptsis et al. (1) describe a new algorithm to determine the immunogenicity of a mismatched human leukocyte antigen (HLA) alloantigen with respect to the humoral immune response. Both in organ and hematopoietic stem-cell transplantation, the best transplant results are obtained with fully HLA-matched donor recipient combinations. However, because of the enormous polymorphis...
متن کاملStructural epitope matching for HLA-alloimmunized thrombocytopenic patients: a new strategy to provide more effective platelet transfusion support?
BACKGROUND During the past three decades, HLA matching for platelet (PLT) transfusion of refractory thrombocytopenic patients has been based on serologic cross-reactivity between HLA-A and HLA-B antigens. Although many blood banks are using this matching strategy, the general experience is that such matched PLT transfusions are often ineffective. STUDY DESIGN AND METHODS This report describes...
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ژورنال
عنوان ژورنال: The Journal of Kansai Medical University
سال: 1989
ISSN: 0022-8400
DOI: 10.5361/jkmu1956.41.3-4_232