HLA-DR4 May Determine Expression of Actinic Prurigo in British Patients
نویسندگان
چکیده
منابع مشابه
Actinic Prurigo: A case report
Actinic prurigo is a rare disease occurring mainly in individuals of American Indian origin and those living in high altitudes. Skin lesions consist of pruritic popular or nodular excoriated lesions mainly affecting exposed skin but covered skin is also involved in up to 50% of patients. This is the first case report of an Iranian patient. This 19-year-old female had pruritic popular and ...
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This report describes the association of HLA-DR phenotypes in a population of 91 Caucasian melanoma patients compared with 106 Caucasian controls from the Sunbelt region of the United States. Over 75% of both patients and controls were born in Alabama or a surrounding state. There was a significant increase in the frequency of HLA-DR4 (chi 2 = 12.8; rho = 0.0003). This was present in 38.5% of t...
متن کاملApoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry
BACKGROUND Actinic prurigo (AP) is an idiopathic photodermatosis, this entity requires exposure to UV-B and -A to develop lesions. Apoptosis is a physiological death program that can be initiated by a permanently active mechanism (extrinsic pathway) or irreparable damage (intrinsic pathway). MATERIAL AND METHODS Descriptive study, the sample size comprised 64 paraffin blocks of tissue with a ...
متن کاملActinic Prurigo in Scandinavian Adolescent Successfully Treated with Cyclosporine A
Actinic prurigo is a pruritic sun-induced dermatosis classified among the immunologically mediated photodermatoses. The disease is a well-known entity among Native Americans and in Central and South America, however rare in Caucasians with only a few reports from Australia, Britain and France. We report the first case of actinic prurigo in a Scandinavian patient, responding favorably to systemi...
متن کاملInmunohistochemical detection of mastocytes in tissue from patients with actinic prurigo
BACKGROUND Actinic prurigo (AP) is a type of photodermatosis, the pathophysiology of which has not been determined. AP has been suggested to be a hypersensitivity reaction to the presence of eosinophils and the local production of IgE. MATERIAL AND METHODS Descriptive study, using paraffin blocks of tissue that have been diagnosed with AP from the Dermopathology department, Hospital General D...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1996
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12343141