HLA-B*51 the primary risk in Behcet disease

Primary association of HLA-B51 with Behçet's disease in Ireland.

AIMS/BACKGROUND While a primary association of HLA-B51 with Behçet's disease (BD) in Japanese and Mediterranean patients supports an immunogenetic predisposition, this link is unclear in north western Europe. This study assessed HLA associations with BD, and HLA-B51 with certain clinical characteristics, in the Republic of Ireland, which has an ethnically homogeneous population. METHODS HLA-A...

hla-b51 in behçet’s disease

there is some data in the literature on the association of hla-b5 and some manifestations of behçet's disease (bd), especially ocular lesions. we studied 433 patients to see if there was any relationship between b51 and the manifestations of the disease. clinical manifestations of bd were compared in patients having hla-b51 (155 patients) and those lacking hla-b51 (278 patients). oral aphthosis...

Clinical phenotypes of Korean patients with Behcet disease according to gender, age at onset, and HLA-B51.

Background/Aims The clinical manifestations of Behcet disease (BD) have been reported to differ according to country, region, and race. Gender, onset age, and human leukocyte antigen (HLA)-B51 have also been known as the factors that influence the clinical features of BD. The aim of this study is to investigate the clinical phenotypes of Korean patients who visited the rheumatology clinic with ...

HLA-B51 and cigarette smoking as risk factors for chronic progressive neurological manifestations in Behçet's disease.

HLA-B*51 the primary risk in Behçet disease.

Behçet disease (BD) is a multisystem autoinflammatory condition characterized by mucosal ulceration and predominantly neutropilic inflammation of immune privileged sites including the eye, brain, and synovial joint (1). In PNAS, Ombrello et al. analyze a combination of directly ascertained and imputated single nucleotide polymorphisms (SNPs) in the HLA-B region in Turkish patients with BD (2). ...