HLA-B27 and spondyloarthropathy: value for early diagnosis?

HLA-B27 and spondyloarthropathy: value for early diagnosis?

The seronegative spondyloarthropathy complex The seronegative spondyloarthropathy complex embraces a group of inflammatory rheumatic disorders linked together by certain clinical, laboratory, and radiological manifestations. Clinically, the disorders are characterised by asymmetrical peripheral oligoarthritis and involvement of the sacroiliac joints (table 1). Manifestations in the eyes, mucocu...

HLA-B27 associated spondyloarthropathy, an autoimmune disease based on crossreactivity between bacteria and HLA-B27?

Most autoimmune diseases are associated with certain HLA types. Therefore, spondyloarthropathies (SpA) strongly associated with HLA-B27, are also often classified as autoimmune diseases. This study questions whether SpA indeed fulfils the criteria of an autoimmune disease. The Medline database was searched for all reports between 1966 and April 1998 on the presence of autoimmune reactivity in S...

HLA-B27 associated spondyloarthropathy and severe ascending aortitis.

We describe a young woman who developed early and severe aortic regurgitation and subsequent aortitis with aneurysm formation requiring surgery.

How does HLA-B27 affect susceptibility to spondyloarthropathy?

Ankylosing Spondylitis, HLA-B27 and Klebsiella – An Overview: Proposal for early diagnosis and Treatment

Ankylosing spondylitis (AS) is a potentially disabling rheumatic disease for which no curative treatment has yet been discovered. An extensive computer-based and manual search was undertaken to evaluate the role of microbes in the pathogenesis of AS. All together 147 papers were scrutinised. A total of 24 studies carried out on 1330 AS patients and 1191 healthy controls involving 15 different c...