HIV-1/ Mycobacterium tuberculosis Coinfection Immunology: How Does HIV-1 Exacerbate Tuberculosis?
نویسندگان
چکیده
منابع مشابه
Double Scourge: Tuberculosis and HIV Coinfection
uberculosis (tb) has, from ancient times, ranked among the most feared and dreaded of the many diseases that afflict mankind. Over a century since Mycobacterium tuberculosis was discovered and more than 50 years after effective drug treatment was introduced, tb remains a major public health problem. It is now five years since the World Health Organization (who) took the unprecedented step of de...
متن کاملHigh Tuberculosis and HIV Coinfection Rate, Johannesburg
To the Editor: Tuberculosis (TB) is the leading cause of illness and death among HIV-1–infected patients in sub-Saharan Africa (1–3), but valid data on the population-level interaction between the TB and HIV epidemics are scarce (4). Our objective was to determine the extent of this dual epidemic in our setting, a hospital in Johannesburg, South Africa. We did this by introducing bedside TB and...
متن کاملBidirectional Effects of Tuberculosis and HIV Coinfection
In 2008, 1.37 million new cases of tuberculosis (TB) occurred in HIV-infected persons worldwide, with an estimated nearly half-million deaths due to TB in HIV-infected individuals (World Health Organization, 2009). Prevalence rates of TB in HIV infection are highest (≥ 50%) in areas of sub-Saharan Africa and are substantial in many other locales worldwide (Figure 1). Globally, TB is one of the ...
متن کاملChronic Helminth Infection Does Not Exacerbate Mycobacterium tuberculosis Infection
BACKGROUND Chronic helminth infections induce a Th2 immune shift and establish an immunoregulatory milieu. As both of these responses can suppress Th1 immunity, which is necessary for control of Mycobacterium tuberculosis (MTB) infection, we hypothesized that chronic helminth infections may exacerbate the course of MTB. METHODOLOGY/PRINCIPAL FINDINGS Co-infection studies were conducted in cot...
متن کاملHow does Mycobacterium tuberculosis establish infection?
On 16 January 1924, Allen Krause gave an address entitled “The spread of tuberculous infection in the body” before the Bronx County Medical Society, under the auspices of the New York Tuberculosis (TB) Association [1]. He said “few of us, it would seem, think of the possibility of a more general distribution of infection as perhaps the mode of tuberculosis; of bacilli nesting in many places thr...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2011
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.01126-10