HIV-1 Latency and Latency Reversal: Does Subtype Matter?

HIV latency.

HIV-1 can establish a state of latent infection at the level of individual T cells. Latently infected cells are rare in vivo and appear to arise when activated CD4(+) T cells, the major targets cells for HIV-1, become infected and survive long enough to revert back to a resting memory state, which is nonpermissive for viral gene expression. Because latent virus resides in memory T cells, it per...

Bioinformatics and HIV Latency

Despite effective treatment, HIV is not completely eliminated from the infected organism because of the existence of viral reservoirs. A major reservoir consists of infected resting CD4+ T cells, mostly of memory type, that persist over time due to the stable proviral insertion and a long cellular lifespan. Resting cells do not produce viral particles and are protected from viral-induced cytoto...

Combinatorial Latency Reactivation for HIV - 1 Subtypes and Variants 1 Running Title : HIV - 1 Combinatorial Anti - latency Strategies

Title : HIV latency in the humanized BLT mouse 1 Running Title : HIV latency in

word count: 244 20 Main text word count: 4305 21 Copyright © 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.06366-11 JVI Accepts, published online ahead of print on 9 November 2011 on Jne 9, 2017 by gest http/jvi.asm .rg/ D ow nladed fom

An Integrated Overview of HIV-1 Latency

Despite significant advances in our understanding of HIV, a cure has not been realized for the more than 34 million infected with this virus. HIV is incurable because infected individuals harbor cells where the HIV provirus is integrated into the host's DNA but is not actively replicating and thus is not inhibited by antiviral drugs. Similarly, these latent viruses are not detected by the immun...