HIV-1 capsid: the multifaceted key player in HIV-1 infection

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Evaluation of clinical course and laboratory findings in HIV/HTLV-1 co-infection compare with HIV mono infection

Background: In the last 10 years, co-infection of human immunodeficiency virus/human T-cell leukemia virus-1 (HIV/HTLV-1) has emerged as a worldwide health problem. These viruses has the same route to infect human but different effects on CD4 positive T-cells. There was controversial results about the influence of co-infection HIV/HTLV-1 pathogenesis. This study compared clinical course and lab...

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Curvature Concentrations on the HIV-1 Capsid

It is known that the retrovirus capsids possess a fullerene-like structure. These caged polyhedral arrangements are built entirely fromhexagons and exactly 12 pentagons according to the Euler theorem. Viral capsids are composed of capsid proteins, which create the hexagon and pentagon shapes by groups of six (hexamer) and five (pentamer) proteins. Different distributions of these 12 pentamers r...

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Acute HIV-1 Infection.

From the Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill (M.S.C.), and the Duke Human Vaccine Institute, Duke University School of Medicine, Durham (B.F.H.) — both in North Carolina; the University of Alabama at Birmingham, Birmingham (G.M.S.); and the Weatherall Institute of Molecular Medicine and the National Institute for Health Re...

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Triple HIV-1 infection.

2557 tives on racial and ethnic differences in health in late life. Washington, D.C.: National Academies Press, 2004:643-74. 3. HIV/AIDS surveillance report. Vol. 8. No. 2. Atlanta: Centers for Disease Control and Prevention, 1996:28. 4. HIV/AIDS surveillance report. Vol. 15. Atlanta: Centers for Disease Control and Prevention, 2003:12. 5. Jaffe H. Whatever happened to the U.S. AIDS epidemic? S...

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Purinergic Receptors: Key Mediators of HIV-1 Infection and Inflammation

Human immunodeficiency virus type 1 (HIV-1) causes a chronic infection that afflicts more than 30 million individuals worldwide. While the infection can be suppressed with potent antiretroviral therapies, individuals infected with HIV-1 have elevated levels of inflammation as indicated by increased T cell activation, soluble biomarkers, and associated morbidity and mortality. A single mechanism...

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ژورنال

عنوان ژورنال: Nature Reviews Microbiology

سال: 2015

ISSN: 1740-1526,1740-1534

DOI: 10.1038/nrmicro3503