History note: tragedy of Thorotrast

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History of the use and toxicity of thorotrast.

In Lisbon, Professor Egaz Moniz, Nobel Prize laureate in medicine for 1945, pioneered the introduction and use of Thorotrast particularly for the visualization of arteries. He produced a large number of excellent publications which contributed, within 2 to 3 years of its first production, to its widespread adoption throughout Europe, Japan and North America. Moniz was not alone in this pioneer ...

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Long-term hazards of Thorotrast.

As regards changes which could lead to irreversible lowering of cardiac function, the arteritis might prove in the long run the most significant if it progressed. There is no evidence in the affected vessels of obstructive phenomena at the time of the patient's death and no effects on the myocardium were noted. It would seem reasonable to infer that if this necrotizing arteritis was a manifesta...

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ژورنال

عنوان ژورنال: Japanese Journal of Radiology

سال: 2015

ISSN: 1867-1071,1867-108X

DOI: 10.1007/s11604-015-0479-1