Histones stimulate von Willebrand factor release in vitro and in vivo
نویسندگان
چکیده
منابع مشابه
Histones stimulate von Willebrand factor release in vitro and in vivo.
Histones, nuclear proteins that normally package DNA in cells, are increasingly recognized as important mediators of inflammation and thrombosis, and have recently been linked to death in sepsis. They are released during inflammation by activated leukocytes, primarily neutrophils, as part of neutrophil extracellular traps (NETs). Although NETs play an important role in innate immunity, componen...
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von Willebrand factor (vWF), a multimeric protein that mediates platelet adhesion, circulates in association with the procoagulant Factor VIII (FVIII). In previous reports, plasmin was shown in vitro to inactivate FVIII and cleave the vWF subunit extensively, but to cause only a modest decrease in vWF platelet-agglutinating activity. In the present study, the digestion of vWF multimers by plasm...
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BACKGROUND Fibrinogen (Fg) has been considered essential for platelet aggregation. However, we recently demonstrated formation of occlusive thrombi in Fg-deficient mice and in mice doubly deficient for Fg and von Willebrand factor (Fg/VWF(-/-)). METHODS AND RESULTS Here we studied Fg/VWF-independent platelet aggregation in vitro and found no aggregation in citrated platelet-rich plasma of Fg/...
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Von Willebrand factor (VWF) is synthesized in endothelial cells, stored in the form of high molecular weight multimers and released after stimulation. After release, the multimers are cleaved by ADAMTS13 (von-Willebrand-factor-cleaving protease). We studied healthy volunteers in a double-blind, placebo controlled inflammation model. Ten male volunteers received 2 ng/kg endotoxin intravenously, ...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2016
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2015.140632