Histidine aminotransferase activity inStreptomyces tendaeand its correlation with nikkomycin production
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چکیده
منابع مشابه
Identity of rat kidney histidine-pyruvate aminotransferase with glutamine-oxo acid aminotransferase.
Histidine-pyruvate aminotransferase and glutamine-phenylpyruvate aminotransferase were purified from rat kidney by the same procedure. The ratio of the two activities remained constant during purification and was unchanged by a variety of treatments of the purified enzyme. Glutamine was found to act as a competitive inhibitor of histidine-pyruvate aminotransferase. These results suggest that ra...
متن کاملEvidence of a critical histidine residue in soluble aspartic aminotransferase.
Photooxidation of extramitochondrial cy-aspartate aminotransferase in the presence of methylene blue or Rose bengal leads to a loss of enzymatic activity which follows fist order kinetics. Amino acid analysis shows that histidine is the only amino acid residue significantly affected by photooxidation. Of the 8 hi&dine residues present in the enzyme monomer, 2 are oxidized rapidly at a rate iden...
متن کاملOrgan distribution of rat histidine-pyruvate aminotransferase isoenzymes.
The organ distribution of rat histidine-pyruvate aminotransferase isoenzymes 1 and 2 was examined by using an isoelectric-focusing technique. Isoenzyme 1 (pI8.0) is present only in the liver and its activity is increased by the injection of glucagon, whereas isoenzyme 2 (pI5.2) is distributed in all tissues (liver, kidney, brain and heart) tested, and is not affected by glucagon injection. Isoe...
متن کاملCorrelation of serum alanine aminotransferase and aspartate aminotransferase with coronary heart disease.
OBJECTIVE This study aimed to explore the relationship between different risk factors (especially serum alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) and coronary heart disease (CHD). METHODS A total of 610 inpatients were recruited. Initial coronary angiography (CAG) was performed to evaluate the severity of coronary lesions. On the basis of findings from CAG, patients...
متن کاملCloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production
BACKGROUND Nikkomycins are a group of peptidyl nucleoside antibiotics produced by Streptomyces ansochromogenes. They are competitive inhibitors of chitin synthase and show potent fungicidal, insecticidal, and acaricidal activities. Nikkomycin X and Z are the main components produced by S. ansochromogenes. Generation of a high-producing strain is crucial to scale up nikkomycins production for fu...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 1992
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.1992.tb05460.x