Histamine receptors and cancer pharmacology
نویسندگان
چکیده
منابع مشابه
International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.
Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues. Its physiological functions are mediated by four 7-transmembrane G protein-coupled receptors (H1R, H2R, H3R, H4R) that are all targets of pharmacological intervention. The receptors display molecular heterogeneity and constitutive activity. H1R antagonists are long known antiallergic and sedating drugs, w...
متن کاملInternational Union of Pharmacology. XIII. Classification of histamine receptors.
Department of Physiology and Pharmacology (S.J.H.), Medical School, Queen’s Medical Centre, Nottingham, England; Department of Chemistry (C.R.G.), University College London, Christopher Ingold Laboratories, London, England; Department of Pharmacochemistry (H.T.), Leiden/Amsterdam Center for Drug Research, Vrije Universiteit, Amsterdam, The Netherlands; Unité de Neurobiologie (J.C.S.), Paris, Fr...
متن کاملHistamine, histamine receptors and antihistamines: new concepts.
Drugs with antihistamine action are the most commonly prescribed medication in daily dermatologic practice, both to adults and children. This article addresses new concepts of the role of histamine receptors (H1 receptors) and discusses the anti-inflammatory effects of these drugs. Second generation antihistamines differs from first generation because of their high specificity and affinity for ...
متن کاملHistamine Receptors
Dr. Iwan de Esch is an assistant professor and Prof. Rob Leurs is full professor and head of the Division of Medicinal Chemistry of the Leiden/Amsterdam Center of Drug Research (LACDR), VU University Amsterdam, The Netherlands. Since the seventies, histamine receptor research has been one of the traditional themes of the division. Molecular understanding of ligand-receptor interaction is obtain...
متن کاملIntracerebroventricular Injection of Histamine Induces State-Dependency through H1 Receptors
The aim of the present study was to investigate whether and by which mechanism; histamine can induce state-dependent retrieval of passive avoidance task. The pre-training or pre-test intracerebroventricular (i.c.v.) injection of histamine (20µg/mouse) impaired retrieval, when it was tested 24 h later. In the animals, which retrieval was impaired due to histamine pre-training administration, pre...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2010
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.2010.00961.x