Histamine H4Receptor Mediates Chemotaxis and Calcium Mobilization of Mast Cells
نویسندگان
چکیده
منابع مشابه
Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells.
The diverse physiological functions of histamine are mediated through distinct histamine receptors. Mast cells are major producers of histamine, yet effects of histamine on mast cells are currently unclear. The present study shows that histamine induces chemotaxis of mouse mast cells, without affecting mast cell degranulation. Mast cell chemotaxis toward histamine could be blocked by the dual H...
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e have known about histamine receptors in the heart for any years (1). The human H1and H2-histamine recepors were cloned and characterized in the early 1990s (2,3), ollowed closely by the human H3and H4-histamine eceptors several years later (4,5). Histamine is a natural ody constituent that is found throughout the body, espeially the central nervous system, mast cells, gastric mucosa arietal c...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Experimental Therapeutics
سال: 2003
ISSN: 0022-3565,1521-0103
DOI: 10.1124/jpet.102.046581