Highly Selective Inhibitors of Class II Microbial Fructose Bis-phosphate Aldolases
نویسندگان
چکیده
منابع مشابه
Inactivation of class I fructose diphosphate aldolases by the substrate analog N-bromoacetylethanolamine phosphate.
N-Bromoacetylethanolamine phosphate, prepared by the bromoacetylation of ethanolamine phosphate, has been tested as an active site-specilic reagent for rabbit and rat muscle fructose diphosphate aldolases. The reagent inactivates both enzymes, and inactivation is prevented by substrates or competitive inhibitors. Loss of activity is pseudo-first order until the later stages of inactivation, and...
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متن کاملInactivation of Class I Fructose Diphosphate Aldolases by the Substrate Analog N-Bromoacetylethanolamine
N-Bromoacetylethanolamine phosphate, prepared by the bromoacetylation of ethanolamine phosphate, has been tested as an active site-specilic reagent for rabbit and rat muscle fructose diphosphate aldolases. The reagent inactivates both enzymes, and inactivation is prevented by substrates or competitive inhibitors. Loss of activity is pseudo-first order until the later stages of inactivation, and...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2010
ISSN: 1948-5875,1948-5875
DOI: 10.1021/ml100017c