Highly purified insulins

A clinical comparison of purified bovine and purified porcine insulins.

Twenty four patients with established insulin dependent diabetes treated with twice daily soluble and isophane bovine insulins were changed to equivalent doses of either purified bovine Neusulin and Neuphane (Wellcome) or purified porcine Actrapid and Monotard (Novo) insulins. After 6 months treatment the porcine group showed a 35% fall in insulin binding antibodies and a 14% reduction in insul...

Lipohypertrophy and lipoatrophy complicating treatment with highly purified bovine and porcine insulins.

Lipoatrophy and lipohypertrophy were the most frequently reported local complications of conventional insulin therapy. Early reports following the introduction of highly purified insulins suggested a reduction in the frequency of lipohypertrophy and lipoatrophy. Since highly purified insulins have been in common usage for 10 years, the present frequency of these complications was assessed in a ...

Paradoxical lipodystrophic changes due to conventional bovine and highly purified porcine/bovine insulins.

A 78-year-old woman developed marked insulin lipoatrophy due to conventional bovine insulin injected into the upper limbs. Changing to a combination of highly purified porcine/bovine insulins injected into the lower limbs resulted in the opposite effect, namely insulin-induced lipohypertrophy. Use was then made of this effect by injecting the highly purified insulins into the atrophied upper li...

Allergy to purified bovine, porcine, and human insulins.

Properties of highly purified fucan.

Fucan was first isolated by Kylin from brown seaweed and named fucoidin by him (1). More recently fucan was isolated by Percival and Ross (2) from several Phaeophyceae. They considered it to be a polymeric salt of fucose monosulfate. However, their most highly purified preparation still contained approximately 5.6% sugars other than L-fucose and 3.3 ‘% uranic acid. A branched structure was sugg...