Highly performing graphene-based field effect transistor for the differentiation between mild-moderate-severe myocardial injury

Cardiovascular diseases result in millions of deaths around the globe, many which could have been avoided if identified at an early stage. Preventive cardiovascular disease diagnostics plays a vital role reducing critical fatality rate by allowing to take timely necessary precautions. Here, we demonstrate exceptional properties aptamer modified graphene-based FET (GFET) for cardiac troponin I (cTnI) specific sensing different bodily fluids. Concentration-dependent measurements made with on aptamer/polyethylene glycol (PEG) GFET exhibited real-time detection cTnI from 1 400 pg mL?1 0.01 × phosphate-buffered saline (PBS) solution. The sensor performance is within clinical important window 10 500 mL?1, differentiation between healthy, and people low high risk myocardial infraction (AMI). Even more very reproducible shift neglectable leakage current individual IDSVGS-curves upon contact solutions. To further evaluate applicability developed point care device serum, samples 15 patients levels were analysed their levels. grouped according magnitude peri-operative injury as assessed hs-cTnT assay into mild (cTnT<15 mL?1), moderate (15 mL?1>c-TnT<500 mL?1) severe (cTnT>500 cases. allowed categorise all correctly corresponding 3 zones (respectively, low, medium high). While indeed larger patient sample collection required assessments, these data seem highly promising.